• Senior Scientist , CryoEM , Structural & Molecular Sciences Jobs in United States Of America

  • Pfizer Inc.
  • United States Of America, Usa

Job Description:

ROLE SUMMARY

We have an open position at the Senior Scientist level for a cryo-EM position in the Structural and Molecular Sciences (SMS) group at our Groton, CT Pfizer Research and Development campus The SMS group is a multidisciplinary group with established expertise in molecular biology, protein biochemistry, protein mass spectrometry, enzymology, NMR, biophysics, protein X-ray crystallography and cryo-EM Our mission is to provide integrated molecular insights into drug targets, lead compounds and target-compound & -antibody interactions to advance discovery efforts across multiple therapeutic areas, including Inflammation and Immunology, Vaccines, Biologicals, Cardiovascular and Metabolic Diseases and Rare Diseases

We are equipped with an FEI Titan Krios microscope with a Gatan K2 Summit direct electron detector, GIF energy filter and Volta Phase Plate for high resolution data collection, a FEI TF20 microscope with a Gatan OneView detector for sample characterization, and a dedicated computer cluster and GPU boxes for data processing and refinement We have already been successful in application of cryo-EM technology to several Pfizer projects

As a Senior Scientist, you will have broad experience or familiarity with different aspects of structure determination by cryo-EM technology including sample preparation, data collection, data processing using state-of-art software, and 3-D reconstruction We are looking for someone who is passionate about the hardware and computing skills associated with EM such as microscope, direct electron detector, sample robot, computer cluster, etc and their maintenance Equally important will be your ability to collaborate successfully with other scientists in the department and with biologists and chemists in multiple drug discovery teams You will eventually be expected to understand the critical issues and challenges faced by different drug discovery programs within Pfizer and design suitable experimental strategies based on cryo-EM techniques to positively impact drug discovery

ROLE RESPONSIBILITIES

As part of the EM team, help manage, maintain and develop the facility, supports users, and lead collaborative projects aimed at improving our cryo-EM infrastructure and scientific research program
Leveraging your cryo-EM expertise, provide consultation and guidance to colleagues from other SMS labs for EM studies and serve as a valuable resource for the entire department
Independently undertake cryo-EM studies of targets that are of interest to Pfizer The proposed work will involve all aspects of cryo-EM structure determination including preparation of suitable grids, analysis by negative staining, cryo-EM data collection, class averaging, 3D-reconstruction and refinement
Deliver novel scientific insights for the design of small molecule ligands as well as biologicals, vaccines and viral capsids for gene therapy
Establish productive collaborations with other SMS colleagues and form partnerships with colleagues from research units and other departments
Rapidly advance projects by timely problem solving and crisp decision making
Clearly communicate with project team members and other Pfizer colleagues
Consistently record your experimental results in an electronic laboratory notebook and comply with all Pfizer safety policies

BASIC QUALIFICATIONS

Doctoral degree or equivalent in Biochemistry, Biophysics, Physics, Chemistry or related field
Postdoctoral training in cryo-EM with 1-3 years of industrial or academic experience
Proven ability to independently design and conduct state-of-the-art single particle cryo-EM experiments, leading to a strong track record of successful outcomes with publications in top tier journals
Must be able to thrive and deliver results in a fast paced, dynamic and highly multi-tasking environment
Broad knowledge in protein characterization, structural biology, biophysics and computational chemistry
Demonstrated ability to work independently and in teams in an inclusive manner
Proven scientific influence via strong interpersonal and communication skills; passionate about using structural data to influence key scientific decisions Has the skill and drive to grow into a thought leader

PREFERRED QUALIFICATIONS

Broad experience or familiarity with different aspects of structure determination by cryo-EM technology including sample preparation, data collection, data processing using state-of-art software, and 3-D reconstruction
Passionate about the hardware and computing skills associated with EM such as microscope, direct electron detector, sample robot, computer cluster, etc and their maintenance
Ability to collaborate successfully with other scientists in the department and with biologists and chemists in multiple drug discovery teams

PHYSICAL/MENTAL REQUIREMENTS

Ability to perform complex data analysis and to communicate results to management and external peers

Must be able to work safely in a laboratory environment with lab coat, protective eye wear, and gloves

The job requires standing and walking on a daily basis

Profile Summary:

Employment Type : Full Time
Eligibility : Any Graduate
Industry : Biotechnology/Pharmaceutical/Medicine, Manufacturing/Industrial
Functional Area : Bio Tech/R&D/Scientist
Role : Bio-Technology Research
Salary : As per Industry Standards
Deadline : 16th Mar 2020

Key Skills:

Company Profile:

Company
Pfizer Incarfix

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