• Scientist, Cancer Biology Jobs in New York City - 23759004

  • Pfizer Inc.
  • New York City
  • Save Job
  • 6 - 9 Years
  • Posted : above 1 month

Job Description:

The successful candidate will work independently or as part of a research team that is focused on developing and running functional genomic screens and identifying new targets for the OTD department Use of shRNA or CRISPR technology platforms to screen and identify targets regulating oncology and or immune related disease pathways is essential He/she will also provide weekly assay development , cell culture, and molecular biology support for different projects and programs


Pfizer Integrative Biotechnology Group (IBG) located in Pearl River, NY is within the Oncology division of Pfizer Worldwide Research & Development IBG is dedicated to developing the next generation oncology therapeutics and therapeutic combinations by employing a multidisciplinary approach to target cancer cell cycle and modulate tumor microenvironment We are seeking a qualified candidate at the Scientist level to join the group to contribute to drug discovery efforts by applying functional genomics and advanced molecular biology strategies to study novel cellular mechanisms underlying synthetic lethality with Pfizers preclinical and clinical assets Primary responsibility of this role includes generating data packages to support advancement of late stage projects and publications in top-tiered research journals

The qualified candidate for this position will be a highly motivated and collaborative scientist with strong interest in cancer biology, epigenetics, cell cycle progression and/or senescence response

S/he will demonstrate clear and professional verbal and written communication skills, maintain an electronic notebook, and can present scientific results to collaborators and at team meetings


Perform experiments to study genetic and epigenetic factors that promote tumor growth and maintenance
Develop cellular and molecular assays to define mechanism of action relevant to target inhibition either by genetic approaches or compound treatment
Perform cell-based assays for drug response alone or in combination to identify drug synergy
Perform RNAi/CRISPR-based functional genomics screens for target discovery and validate novel drug targets both in vitro and in vivo
Present experiment results in group meetings
Maintain experimental records in electronic lab notebook
Share common lab responsibilities such as lab supply order and inventory management
Contribute to a dynamic, exciting culture that embraces teamwork and innovation


BS degree with 6 years of experience or MS degree with 5 years of experience in molecular biology, cell biology, genetics or related discipline
Minimum 5 years of hands-on laboratory research
Ability to plan and execute in vitro and/or ex vivo experiments with minimal supervision
Experience in cell culture, flow cytometry, cell-based assays and standard molecular biology techniques such as SDS-PAGE, ELISA, Western Blot, DNA/RNA purification, PCR/RT-PCR, and lentiviral packaging & transduction
Experience with data processing software including Excel and Prism
Excellent organization and planning skills, the ability to work independently or as part of a team, good verbal & written communication and interpersonal skills, and strong motivation with a pro-active attitude and dedicated work ethic
Ability and desire to learn new techniques


Experience in cancer biology especially in cell cycle regulation and cancer epigenetics
Knowledge of RNAi technology and experience in pooled RNAi-based screens
Experience in use of CRISPR-based techniques for gene knockout, gene editing as well as working knowledge of pooled CRISPR-based screening approaches
Experience with NextGen sequencing
Experience with tumor cell dissociation and processing

Profile Summary:

Employment Type : Full Time
Eligibility : Any Graduate
Industry : Biotechnology/Pharmaceutical/Medicine, Manufacturing/Industrial
Functional Area : Bio Tech/R&D/Scientist
Role : Bio-Technology Research
Salary : As per Industry Standards
Deadline : 06th Apr 2020

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