• United States Of America, Usa
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  • 0 - 3 Years
  • Posted : above 1 month

Job Description:

If youre inspired by the possibilities of science to change lives and you thrive when making brave decisions join us

MedImmune is the worldwide biologics research and development arm of AstraZeneca Here, youll have the opportunity to make a difference in peoples lives every day As one of the worlds premier biotechnology companies, our mission is centered on delivering life-changing products that advance world health, and help fight and cure disease Here at MedImmune, youll play a pivotal role in channeling our scientific capabilities to make a positive impact on changing patients lives

Were constantly pushing the boundaries of science to deliver life-changing medicines to patients, with a passion for discovery and a pipeline to show for it Were pioneering innovative research and exploring novel pathways across key therapeutic areas including oncology, respiratory, inflammation and autoimmunity, cardiovascular and metabolic disease, and infection and vaccines And were industry-leading in immunology, protein engineering and translational science We offer a unique and strong collaborative network as part of the AstraZeneca family, as together we explore synergies between small and large molecules

MedImmune has a dynamic environment that fosters collaboration and innovation We attract top minds, and we nurture and build top talent

This position is a hands-on, laboratory-based role

This role will

Develop and characterize downstream processes for the manufacture of biopharmaceuticals (monoclonal antibodies and other proteins) in late stage clinical development through commercial launch

Be responsible for a portion of a purification development project o Make observations, analyze data and interpret results

Maintain accurate records of experimental results, review, analysis, and interpretation of experimental data

Make periodic presentations in group meetings, project team meetings, and in one-on-one situations

Prepare/review development reports, tech transfer and process validation documents, regulatory submissions

Support technology transfer to Clinical/Commercial Manufacturing facilities

Support troubleshooting and resolution of deviations in GMP manufacturing processes

Evaluate of new technologies to facilitate process development

Position Requirements
R&D Associate I requires a Bachelors Degree with some relevant industrial experience preferred

Education Bachelors Degree in Biochemistry, Chemical Engineering, or related field

* Proficiency in protein purification principles and methods including (but not limited to) different modes of chromatography, viral removal/inactivation steps and filtration
* Knowledge of o Basic protein chemistry; protein and analytical chemistry, process robustness concepts and process scale-up o Working knowledge of good laboratory practices o Purification process design o Basic analytical techniques for protein products (HPLC analysis, protein quantification methods, electrophoresis; etc) o AKTA systems/software
* Highly team-oriented, energetic, critical thinker, organized, capable of significant multitasking with excellent oral and written communication skills
* Experience considered a plus o Statistical design of experiments (DOE) o Process scale-up and technology transfer o cGMP manufacturing principles and environments o Process validation o Familiarity with risk assessments and Regulatory submissions (especially BLA) o Purification of protein-based therapeutics other than antibodies (eg conjugates, bispecifics, fusion proteins or products produced by microbial systems)

AstraZeneca embraces diversity and equality of opportunity We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills We believe that the more inclusive we are, the better our work will be We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorisation and employment eligibility verification requirements

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Profile Summary:

Employment Type : Full Time
Eligibility : Any Graduate
Industry : Biotechnology/Pharmaceutical/Medicine, Manufacturing/Industrial
Functional Area : Bio Tech/R&D/Scientist
Role : Bio-Technology Research
Salary : As per Industry Standards
Deadline : 18th Mar 2020

Key Skills:

Company Profile:

Company
ASTRAZENECA PHARMA INDIA LTDarfix

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