• United Kingdom, Uk
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  • 0 - 3 Years
  • Posted : above 1 month

Job Description:

At AstraZeneca, we turn ideas into life changing medicines Working here means being entrepreneurial, thinking big and working together to make the impossible a reality

AstraZenecas Centre for Genomics Research (CGR) are looking for outstanding Genome Analysts to contribute to the genomic strategies of the CGR in an unprecedented genomic initiative, involving the analysis of up to 2 million genomes This includes the analysing the sequences of up to 500,000 participants from AstraZeneca clinical trials and the sequence data from large population cohorts including the ~500,000 UK Biobank participants

Genomics is fundamental to our laboratory research, our clinical trials and the launch of new precision medicines Our in-house clinico-genomic database is already among one of the largest globally, currently housing hundreds of thousands of human exome and genome sequences to enable AstraZeneca to identify genetic determinants for disease risk, validate new targets for medicines and improve patient stratification opportunities among core therapeutic areas of oncology, respiratory, cardiovascular, renal and metabolic disease

Genome Analysts will work with leaders in human genomics, designing and implementing novel statistical genetic approaches on large-scale genomics data and delivering innovative science to genome analytics Genome Analysts are responsible for the analysis of CGR projects with support from a dynamic team in CGRs multidisciplinary genomics research environment comprising of bioinformaticians, computational biologists, software engineers, statistical geneticists, postdoctoral researchers and clinician experts You will also work closely with experts in translational science, drug discovery, pre-clinical modelling, and clinical development; thus, contributing to the broader objectives and success of the company-wide Genomics Initiative

Responsibilities

Coordinating and executing analyses within AstraZenecas Centre for Genomics Research
Applying innovative quantitative genomic analyses to large-scale cohort studies to identify clinically relevant disease and response loci
Deliver novel insights into the biology of disease, validation of new targets for medicines and the improvement of selection of patients for clinical trials
Assessing the scientific & technical integrity of algorithms and tools within the analysis pipeline
Providing detailed reports regarding the study design, analysis approach and research findings and presenting to study teams
Maintaining a well-developed knowledge of genomic science and technical advances in the international community
Leading genomic science input into the drug development process
Collaborating to apply genomic analysis with discovery and development teams
Ensuring own work, and work of team, is compliant with Good Laboratory Practice, Safety, Health and Environment standards and all other internal AstraZeneca standards and external regulations

Qualifications, Skills and Experience Required

Essential

PhD degree (or equivalent experience) in Bioinformatics, Statistical Genetics, Biostatistics, Complex Trait Genetics, Computational Biology, or a related discipline
Experience in large-scale data analysis, applied statistics, and machine learning
Ability to communicate effectively with team members and non-experts, both verbally and through documentation
High level understanding or interest in the potential of genomics to impact drug discovery
Ability to prioritize, problem-solve and perform difficult tasks while under pressure
Ability to carry out duties under minimal supervision
Excellent interpersonal skills and willingness to work within a team in a quickly evolving environment
Track record of peer-reviewed publications in high-level scientific journals

Desirable

Previous experience in a similar role
Experience in case-control sequencing based statistical analyses
Experience quantifying and interpreting the clinical relevance of rare variants
Familiarity with high performance and/or cloud computing
Programming skills appropriate for large scale genomics analysis
Familiarity working on genomics studies involving one of AstraZenecas core therapeutic areas

Location Melbourn Science Park, Cambridge, UK

Salary Competitive Excellent Benefits

If you are interested, please apply

AstraZeneca is an equal opportunity employer AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, gender or gender orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law

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Profile Summary:

Employment Type : Full Time
Eligibility : Any Graduate
Industry : Biotechnology/Pharmaceutical/Medicine, Manufacturing/Industrial
Functional Area : Bio Tech/R&D/Scientist
Role : Bio-Technology Research
Salary : As per Industry Standards
Deadline : 16th Mar 2020

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